MOTS-c stands as a brief peptide encoded within the mitochondrial genome, belonging to the broader category of mitochondrial-derived peptides (MDPs). These MDPs, recently recognized as bioactive hormones, assume crucial roles in mitochondrial intercommunication and energy management. Initially associated solely with mitochondria, current research reveals that numerous MDPs actively function within the cell nucleus and some even traverse into the bloodstream, exerting systemic effects. MOTS-c, a newly identified MDP, has emerged as a significant player in metabolism, weight regulation, enhancing exercise capacity, extending longevity, and influencing processes linked to conditions like osteoporosis. This peptide has been detected in cell nuclei and circulatory systems, solidifying its status as a genuine natural hormone. In the past five years, intensive research has been directed toward MOTS-c due to its promising therapeutic prospects.
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